Been a while since I posted but...
Watched the Villa and Sheffiled United games and have missed the rest so correct me if I'm wrong, but I'm afraid Mepham, despite his potential, should be on the bench. The best defence is Ake and Cook in the middle, not Ake at LB and Mepham/Simpson with Cook. People say he played there at Watford and got Young Player of the Year but let's be fair there was not a lot of competition. And also consider that was nearly four years ago... his primary position is CB. The chemistry between Cook and Ake has been existent for a few years now, they don't need to tell each other where they are. They already know it. Hence why the defence, from what I have read on here, is a shambles.
Ake out of position, Mepham (with his lack of experience in the PL and, consequently, his nervousness) and Cook hardly playing games together means that there is a lack of communication, and this contributed to the loss at Leicester, amongst other factors of course.
For Everton, Cook and Ake need to be back in the centre if we have any chance of winning without conceding a bucket load. Everton's attack is dangerous, and with Smith potentially missing the game, I would rather have Ake at CB than LB, and Mepham on the bench. Stacey at RB and Rico at LB; that's if every injured defender misses this game.